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On a field trip to a Columbia University lab, Peter is bitten by a genetically altered spider and overnight he gains superhuman strength, agility, and perception.
At first, Peter uses his powers for material gain, winning a wrestling match with a purportedly lucrative prize. But when Peter apathetically fails to stop a burglar from robbing the wrestling arena, a tragedy follows that compels him to devote his powers to fighting crime -- as the superhero Spider-Man. When he's not busy fighting crime in a spider suit, Peter moves into an apartment with his best friend, Harry (James Franco), and begins work as a photographer at the Daily Bugle.
Meanwhile, his do-gooder alter ego finds a nemesis in the form of the Green Goblin (Willem Dafoe), a super-powered, megalomaniacal villain who happens to be the alter ego of the Harry's father, weapons-manufacturing mogul Norman Osborn.
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